Bruce M. Cohen, MD, PhD

Bruce M. Cohen, MD, PhD

Professor of Psychiatry

Research Roles/Affiliations

Director, Program for Neuropsychiatric Research, McLean Hospital

Robertson-Steel Professor of Psychiatry, Harvard Medical School

Contact Information

Mailman Research Center, Room 303

McLean Hospital, 115 Mill Street, Belmont, MA 02178


Relevant Links

McLean Hospital profile

Harvard University profile

BBR Foundation profile

Harvard Catalyst profile


Our group studies the psychotic disorders, including the schizophrenias and bipolar disorders, as well as neurodegenerative disorders, which are common in late life in those with mood and psychotic disorders. Currently, our research is primarily on cells that have been reprogrammed to neural and glial lines, grown in 2D and 3D cultures, including organoids. Alterations in various structural features and biochemical processes are associated with specific neuropsychiatric disorders and may provide guidance on new therapeutic interventions. Through collaborations, clinical, genomic, and brain imaging data are available on the patients and healthy controls who donate cell lines.

Research Interests

Psychotic Disorders

Bipolar Disorders

Alzheimer’s disease

Neurodevelopment and neurodegeneration

In vitro cell culture and organoid models