Dara S. Manoach, PhD
Professor of Psychology
Department of Psychiatry, Massachusetts General Hospital
Department of Psychiatry, Harvard Medical School
Athinoula A. Martinos Center for Biomedical Imaging at MGH
Massachusetts General Hospital, Charlestown Navy Yard,
149 13th St. Room 2618, Charlestown, MA 02129
The Sleep, Cognition and Neuropsychiatry Laboratory (SCAN Lab) studies is using state-of-the-art complementary multimodal neuroimaging techniques including MEG, EEG, and functional MRI as well as intracranial recording studies to investigate the contribution of abnormal sleep to disabling cognitive deficits and symptoms of schizophrenia, autism spectrum disorder and pediatric epilepsy. We are guided by the principle that understanding the bases of cognitive deficits – from genes to physiology to circuit dysfunction to diagnosis – will lead to effective prevention and treatment. Our group has identified deficient sleep-dependent memory consolidation among the cognitive deficits of schizophrenia, has linked this deficit to specific brain oscillations during sleep, and are developing and evaluating novel mechanistically targeted treatments. The ultimate goal of this research program is to transform the understanding and treatment of neurodevelopmental disorders, to prevent their onset and to improve outcomes.